Sandosh Padmanabhan, in Handbook of Pharmacogenomics and Stratified Medicine, 2014 18.2.4.2 Therapeutic Index The therapeutic index is the relationship between the therapeutic and toxic dose of a given drug and is calculated using the ED 50 and TD 50: Therapeutic Index TD50 ED 50 ED 50 is the dose required to produce a therapeutic effect in 50 of the population; TD 50 is the dose required to produce a toxic effect in 50 of the population; both are calculated from doseresponse curves.The therapeutic index is shown in Figure 18.7.
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